飯塚病院呼吸器内科のブログ
by res81
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福岡県の飯塚病院呼吸器内科のブログです。

呼吸器内科スタッフ10名+呼吸器腫瘍内科スタッフ1名+後期研修医4名(H29年4月現在)で、日々楽しく頑張っています。
大学の医局に関係なく、様々なバックグラウンドのドクターが集まっています。

飯塚病院呼吸器内科では、後期研修医やスタッフを募集しています。ご興味のある方は
iizukakokyu@gmail.com までご連絡ください。

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ATS⑤~Clinical Year in Review~

お疲れ様です。Ajです。いつもブログにお付き合い頂きありがとうございます。ただいま、無事に日本に帰ってまいりました!!
成田でうどんを食べたのですが、日本の出汁の味にほっとしました。

それでは、ATSのClinical Year in Review Part2をお送ります。
COPD、BA、TB/NTMをまとめました。
BAだけ事後資料がなく、講演中にメモしたもののみとなり、文献が少なくなっています。

見にくいですがご容赦ください。


COPD
①「SCREENING FOR COPD」
Siu AL,et al.Screening for Chronic Obstructive Pulmonary Disease:US Preventive Service Task Force Recommendation Statement.JAMA 2016;315:1372-7.
②「SYMPTOMATIC SMOKERS WITH PRESERVED SPIROMETRY」
Woodruff PG et al.Clinical Significance of Symptoms in Smokers with Preserved Pulmonary Function.N Engl J Med 2016;374:1811-21.
③「SUPPLEMENTAL OXYGEN IN COPD」
Long-Term Oxygen treatment Trial Research Group.A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation.N Engl J Med 2016;375(17):1617-1627.
④「DUAL BRONCHODILATORS AND COPD EXACERBATIONS」
Wedzicha JA et al.Indacaterol-Glycopyrronium versus Salmeterol-Fkuticasone for COPD.N Engl J med 2016;372:2222-34.
⑤「ICS/LABA AND CARDIOVASCULAR MORTALITY IN COPD」
Vestbo J et al.Fluticasone Furoate and vilanterol and survival in chronic obstructive pulmonary disease with heightened cardiovascular risk(SUMMIT):a doubke-blind randomised controlled trial.Lancet 2016;387:1817-26.
⑥「EFFICACY OF ICS/LABA IN A 'REAL WORLD'SETTING」
Vestbo J et al.effectiveness of Fluticasone Furoate-Vilanterol for COPD in Clinical Practice.N Engl J Med 2016;375:1253-1260.
⑦「OTHER ARTICLES OF INTEREST」
EPIDEMIOLOGY 
・Allinson JP et al.The Presence of Chronic Mucus Hypersecretion Pulmonary Disease Development.Am J Respir Crit Care Med 2016;193(6):662-72.
DIAGNOSIS
・Jordan RE et al.Targeted case finding for chronic obstructive pulmonary disease versus routine practice in primary care(Target COPD):a cluster-randomised controlled trial.Lancet Respir Med 2016;4(9):720-730.
・Martinez FJ et al.A New Approch for Identifying Patients with Undiagnosed COPD.Am J respir Crit Care Med 2016.
TREATMENT
・Sciurba FC et al.Effect of endobronchiak Colis vs. Usual Care on exercise Tolerance in patients with Severe Emphysema:JAMA 2016;315(20):2178-89.
・Lindson-Hawley n et al.Gradual versus Abrupt Smoking Cessation.Annals of Internal medicine.2016;164:585-592.
・Pascoe S et al.Blood eosinophil counts,exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: a secondary analysis of data from two parallel randomised controlled trials.Lancet respir Med 2015;3(6):435-42.
・Martinez FJ et al.Effect of Roblumilast and Inhaled Corticosteroid/Long-Acting Beta2-Agonist on COPD exacerbations(RE(2)SPOND).A randomized Clinical Trial.Am J Respir Crit Care Med 2016;194(5):559-64.
・Pavord I et al.Blood Eosinophil count and pneumonia risk in patients with chronic obstructive pulmonary disease: a patient-level meta-analysis.Lancet Respir Med 2016;4(9):681-683.
・Singh D et al.Single inhaler triple therapy versus inhaled corticosteroid plus lomg-acting Beta2-agonist therapy for COPD(TRILOGY): a double-blind,parallel group,randomized controlled trial.The Lancet 2016;388.
MECHANISM
・Bhatt SP et al.COPDGene Investigators.Association between Functional Small Airway Disease and FEV1 Decline in COPD.Am J Respir Crit Care Med.2016;194(2):178-84.
・Wain LV et al.Novel insighs into the genetics of smoking behavior, lung function, and chronic obstructive pulmonary disease(UKIBiLEVE): a genetic association study in UK Biobank.Lancet Respir Med.2015;3(10):769-81.
・Dransfield MT et al.Lung Function Loss in Smokers with and without Chronic Obstructive Pulmonary Disease.Am J Respir Crit Care Med.2016 Aug 24.


Asthma

①「Pathogesesis」
・Stein MM et al.Innate Immunity and asthma Risk in Amish and Hutterite Farm Childlen.N Engl J Med 2016;375:375:411-421.
・Peters MC et al.Plasma Interleukin-6 Concentration,metabolic Dysfunction and Asthma severity :A Cross-Sectional Analysis of Two Cohorts.Lancet respir Med.2016;4:574-84.
②「Phenotypes」
・Lefaudeux D et al.U-BIOPRED Clinical Adult Asthma Clusters Linked to a Subset of Sputum Omics.J Allergy and Clin Immu.2016 Oct 20.pii:S0091-6749(16)31185-X.
③「Safety of Asthma Therapies」
・Risk of Serious Asthma-related Events with Budesonide Plus Formoterol vs Budesonide Alone:a Randomized Trial.N Engl J Med 2016;375:850-60.
④「Biologic Therapies:Severe Asthma」
・Ortega HG et al.Severe Eosinophilic Asthma Treated with Mepolizumab Stratufied by baseline Eosinophil Thresholds:A Secondary Analysis of the DREAM and MENSA Studies.Lancet Respir Med.2016;4:549-56.
・Geoffrey L Chupp et al.Efficacy of mepolizumab add-on therapy on health-related quality of life and markers of asthma control in severe eosinophilic asthma (MUSCA): a randomised, double-blind, placebo-controlled, parallel-group, multicentre, phase 3b trial.Lancet Respir Med. 2017 May;5(5):390-400.
・Bleecker ER et al.Efficacy and Safety of Benralizumab for Patients with Severe Asthma Uncontrolled with high-dosage Inhaled Corticosteroids and Long-action β2-agonists(SIROCCO).Lancet.2016;388:2115-2127.
・Hanania NA et al.Efficacy and Safety of Lebrikizumab in Patients with Uncontrolled asthma(LAVOLTA and LAVOLTA Ⅱ).Lancet Respir Med.2016;4:781-796.
・Wenzel S et al.Dupilumab Efficacy and Safety in Adult with Uncontrolled Persistent Asthma Despite Use of Mediumu to High Dose Inhaled Corticosteroids Plus a long-acting β2 Agonist.Lancet.2016;388:31-44.
⑤「OTHER ARTICLES OF INTEREST」
The Host Microbiome In Asthma
・Durack J et al.Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment.J Allery Clin Immunol.2016 Nov 10. pii: S0091-6749(16)31283-0.

抗酸菌感染症(TB/NTM)
①「LATENT TUBERCULOSIS INFECTION」
・Mancuso JD et al.The preverence of latent tuberculosis infection in the United States.Am J Respir Crit Care Med.2016;194:501-509.
②SCREENING AND TREATMENT OF LATENT TB INFECTION
・US Preventive Services Task Force.Screening or latent tubercurosis infection in adults.US Preventive Services Task Force Recommendation Statement.JAMA.2016;316(9);962-969.
③「TREATMENT AND PREVENTION OF TB/HIV」
・Hosseinipour MC et al.Empirical tuberucurosis therapy versus isoniazid in adult outpatients with advanced HIV initiating antiretrovirak therapy(REMEMBER).a multicountry open-label randomized controlled trial.Lancet 2016;387:1198-1209.
④「NONTUBERCULOUS MYCOBACTERIA AND CYSTIC FIBROSIS」
・Bryant JM et al.Emergence and spread of a human-tranmissible-multidrug-resistant nontuberculous mycobavteria.Science 2016;354:751-758.
⑤「TREATMENT OF PULMONARY MYCOBACTERIUM AVIUM COMPLEX」
・Olivier KN et al.Randomized trial of liposomal amikasin for inhalation of nontuberculos mycobacterial lung disease.Am J Respir Crit Care Med 2017 Mar15;195(6):814-823.
⑥「HEAT-COOLER UNIT-RELATED DISSEMINATED MYCOBACTERIUM CHIMAERA」
・Chand M et al.Insidious risk of severe Mycobacterium chimaera infection in cardiac surgery patients.Clin Infect Dis 2017;64:335-342.
⑦「OTHER ARTICLES OF INTEREST」
LATENT TUBERCULOSIS INFECTION
・Miramontes R et al.Tubercrosis infection in the United States:prevalence estimates from the National Health and Nutition Examination Survey,2011-2012.Plos One 2015:10:e0140881.
・Ghassemieh GJ et al.Latent tubercrosis infection test agreement in the National Health and Nutrition Examination Survey.Am J Respir Crit Care Med 2016;194:493-500.
SCREEING AND TREATMENT OF LATENT TB INFECTION
・Kahwati L et al.Primary Care Screening and Treatment for latent Tuberculosis Infection in Adult:ebidence Report and Systematic Review for the US Preventive Services Task Force.JAMA 2016;316(9):970-83.
・Reves R et al.Screening for latent tuberculosis elimination in the United States.JAMA InterMed 2016;176(10):1439-1440.
NONTUBERCULOUS MYCOBACTERIA AND CYSTIC FIBROSIS
・Bryant JM et al.Whole-genome sequencing to identify transmission of Mycobacterium abscessus between patients with cystic fibrosis:a retrospective cohirt study.Lancet 2018;381(9877):1551-60.
・Aitken ML et al.Respiratory outbreak of Mycobacterium abscessus subspecies massiliense in a lung transplant and cystic center.Am J Respir Crit Care Med 2012;185(2):231-2.
TREATMENT OF PULMONARY MYCOBACTERIUM AVIUM COMPLEX
・Olivier KN et al.Inhaled amikacin for treatment of refractory pulmonary nontuberculous mycobacterial disease.Ann Am Thorac Soc 2014;11(1):30-5.
HEAT-COOLER UNIT-RELATED DISSEMINATED MYCOBACTERIUM CHIMAERA
・Sax H et al.Prolonged outbreak of Mycobacterium chimaera infection after open-chest surgery.Clin Infect Dis 2015;61(1):67-75.
・Kohler P et al.Healthcare-associate prosthetic heart valve, aortic vascular graft, and disseminated Mycobacterium chimaera infections subsequent to open heart surgery.Eur Heart J 201a5;36(40):2745-53.

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by res81 | 2017-05-25 21:55 | 学会・研修会 | Comments(0)
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